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1 edition of Toxicology and Carcinogenesis Studies Of Ethylene Glycol (Cas No. 107-21-1) In B6C3F1 Mice,... Technical Report Series... No.413... U.S. Dept. Of Health and Human Services... 1995. found in the catalog.

Toxicology and Carcinogenesis Studies Of Ethylene Glycol (Cas No. 107-21-1) In B6C3F1 Mice,... Technical Report Series... No.413... U.S. Dept. Of Health and Human Services... 1995.

Toxicology and Carcinogenesis Studies Of Ethylene Glycol (Cas No. 107-21-1) In B6C3F1 Mice,... Technical Report Series... No.413... U.S. Dept. Of Health and Human Services... 1995.

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Published .
Written in English


Edition Notes

ContributionsNational Cancer Institute (U.S.)
ID Numbers
Open LibraryOL17698266M

The purpose of this article is to review and interpret the scientific literature on the mammalian toxicity of ethylene glycol (EG) and propylene glycol (PG), with the goal of comparing the toxicity of the two chemicals. This type of review may serve as the basis for risk management decision-making. NTP, National Toxicology Program, , NW Technical Report on the Toxicology and Carcinogenesis Studies of Ethylene Oxide (CAS No. 75–21–8) in B6C3F1 Mice (Inhalation Studies), Board draft, NTP TR , NIH Publication No. 86– Google Scholar.

Get this from a library! NTP technical report on the toxicology and carcinogenesis studies of ethylene glycol (CAS no. ): in B6C3F₁ mice: (feed studies). [National Toxicology Program (U.S.);]. Toxicology and carcinogenesis studies of Ethylene Glycol (CAS No. ) in B6C3F1 mice (feed studies). NTP Technical Report Series No. , NIH Publication No. Research Triangle Park, NC: NTP. Google Scholar.

Ethylene glycol poisoning is poisoning caused by drinking ethylene glycol. Early symptoms include intoxication, vomiting and abdominal pain. Later symptoms may include a decreased level of consciousness, headache, and seizures. Long term outcomes may include kidney failure and brain damage. Toxicity and death may occur after drinking even a small amount. Fundamentals of Toxicology: Essential Concepts and Applications provides a crisp, easy-to-understand overview of the most important concepts, applications, and ideas needed to learn the basics of n by a pre-eminent toxicologist with over five decades of teaching experience, this comprehensive resource offers the hands-on knowledge needed for a strong .


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Toxicology and Carcinogenesis Studies Of Ethylene Glycol (Cas No. 107-21-1) In B6C3F1 Mice,... Technical Report Series... No.413... U.S. Dept. Of Health and Human Services... 1995 Download PDF EPUB FB2

NTP Toxicology and Carcinogenesis Studies of Ethylene Glycol (CAS No. ) in B6C3F1 Mice (Feed Studies) Ethylene glycol is a major constituent of motor vehicle antifreeze-coolant fluids and is also found in other commercial products including hydraulic brake fluids, adhesives, printer's inks, and wood stains.

National Toxicology Program. Toxicology and Carcinogenesis Studies of Ethylene Glycol (CAS No. ) in B6C3F 1 Mice (Feed Studies).

NTP TR U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health, Bethesda, MD. American Conference of Governmental Industrial Hygienists (ACGIH). Experimental Design: Toxicology and carcinogenesis studies of ethylene oxide (greater than 99% pure) were conducted by exposing groups of 50 B6C3F1 mice of each sex to air containing 0, 50, or ppm ethylene oxide, 6 hours per day, 5 days per week for weeks.

These doses were selected because, in week studies, all mice exposed at ppm died within 1 week. The review meeting was held at the National Institute of Environmental Health Sciences, Research Triangle Park, NC.

M.M. McDonald, NIEHS, introduced the toxicology and carcinogenesis studies of ethylene glycol by discussing uses of the chemical and rationale for the study, describing the experimental design, reporting survival and body weight effects, and.

Abstract. Ethylene glycol, or 1,2-ethanediol, is used as an antifreeze in cooling and heating systems, an industrial humectant, an ingredient of electrolytic condensers, a solvent in paint and plastic industries, and in the production of ink.

Teratogenesis, Carcinogenesis, and Mutagenesis. Volume 9, Issue 2. Article. Developmental toxicity screen: Results of rat studies with diethylhexyl phthalate and ethylene glycol monomethyl ether. Richard E. Morrissey. Corresponding Author. Systemic Toxicology Branch, National Institute of Environmental Health Sciences, Research Triangle.

NTP Toxicology and Carcinogenesis Studies of. Book. Jan ; Ethylene glycol itself has a low toxicity but is ra- pidly degraded to toxic metabolites, that are responsible for typical. Toxicological Studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS Nos., ) Administered in Drinking Water to F/N Rats and B6C3F1 Mice.

TOX National Toxicology Program (NTP). Toxicology and Carcinogenesis Studies of 2-Butoxyethanol (CAS No. Ethylene glycol monobutyl ether (EGBE) (2-Butoxyethanol); Principal and Supporting Studies (Oral RfD) NTP (National Toxicology Program) (, ) NTP technical report on the toxicology and carcinogenesis studies of 2 butoxyethanol (CAS No.

76. A subchronic dermal exposure study of diethylene glycol monomethyl ether and ethylene glycol monomethyl ether in the male guinea pig.

Fundam Appl Toxicol. ; 6 (2) Toxicology and carcinogenesis studies of coconut oil acid diethanolamine condensate (CAS No. ) in F/N rats and B6C3F1 mice (dermal studies). TIME COURSE: After ingestion, ethylene glycol is rapidly absorbed (within 1 to 4 hours) through the ing absorption, 80% or more of ethylene glycol is chemically converted by the body into toxic compounds.

The course of ethylene glycol toxicity is classically divided into three broad overlapping categories of adverse health effects. Europe PMC is an archive of life sciences journal literature. NTP technical report on the toxicity studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS Nos., ) Administered in Drinking Water to.

Professor McMartin is an internationally recognized expert in the toxicology of alcohol and ethylene glycol. He has authored numerous papers and made presentations on the toxicology of ethylene glycol at professional gatherings, including a seminar on the mechanism of acute ethylene glycol toxicity in humans at the meeting of the North American.

The developmental toxicity of ethylene glycol was confirmed in a teratology study in rats and mice (Price et al., ). Diethylene glycol at % ( mg/kg per day) in drinking water was a reproductive toxicant in mice based on reductions in the number of litters per pair and in the mean litter size (NTP,Williams et al., ).

NTP, in progress [a]. Toxicology and carcinogenesis studies of Propylene glycol mono-t-butyl ether (CAS No. ) in F/N rats and B6C3F1 mice and a toxicology study of propylene glycol mono-t-butyl ether in male NBR rats (Inhalation studies).

Draft Technical Report Series No. Cited by: 7. Ethylene glycol: environmental aspects 3 industry. They are selected because of their expertise in human and environmental toxicology or because of their experience in the regulation of chemicals.

Boards are chosen according to the range of expertise required for a meeting and the need for balanced geographic representation. Effective Jthe Office of Environmental Health Hazard Assessment (OEHHA) is adding ethylene glycol (ingested) (CAS No.

) to the list of chemicals known to the state to cause reproductive toxicity for purposes of Proposition 65 The listing of this chemical is based on formal identification by the National Toxicology Program (NTP), an authoritative. Subchronic Toxicity of Ethylene Glycol in Wistar and F Rats Related to.

Attachment 2 - Ethylene Glycol - Page 5 of 7. Toxicology and Carcinogenesis Studies of Ethylene Glycol (CAS No. ) in B6C3F1 Mice (Feed Studies). (Study abstract only). National Toxicology Program (NTP). Kinetic and equilibrium studies of ethylene glycol-chromium(III) species in acidic ethylene glycol-water solutions characterization, substitution, and redox studies of bidentate thiol, alkoxy, and related ligands on aquochromium(III) centers.

Inorganic Chemistry16 (1 Books and Reference; Advertising Media Kit; Institutional Sales. Toxicology and carcinogenesis studies of ethylene oxide (greater than 99% pure) were conducted by exposing groups of 50 B6C3F1 mice of'each sex to air containing 0,50, or ppm ethylene oxide, 6.

hours per day, 5 days per week for weeks. These doses were selected be- cause, in week studies, all mice exposed at. ppm died within. Ethylene Glycol is lethal when >1 ml/kg is ingested therefore any deliberate ingestion need prompt intervention.

Commonly found in radiator coolants, antifreeze (concentrations>20%), de-icing solutions, solvents and brake fluids. Unfortunately these products can taste sweet making them appealing to children.ETHYLENE GLYCOL 39 3.

HEALTH EFFECTS INTRODUCTION The primary purpose of this chapter is to provide public health officials, physicians, toxicologists, and other interested individuals and groups with an overall perspective on the toxicology of ethylene glycol.Toxicology is the study of adverse effects of.

chemicals on biological systems. Liver is the chief organ of. (ethylene glycol and alcohol) Receptor antagonism is the. blocking of receptor. Four routes and sites of exposure. but it enhances the carcinogenic properties of a carcinogen.